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White Papers

High-Definition Serology Assessment of SARS-CoV-2, Influenza A and B, Common Coronaviruses, and RSV Respiratory Viral Pathogens using the ZIVA™ Multiplex Array

The recent COVID-19 pandemic has highlighted the importance of studying human immunity to upper respiratory viruses (URVs). Unfortunately, most methods used today for detecting and quantifying antibodies in human samples involve complex workflows and are limited in their multiplex capability (ability to detect many different antibodies at once). Arrayed Imaging Reflectometry (AIR™) provides an ideal solution to this need, without the complexity and limitations of other technologies.

Multiplex Detection of Autoimmunity with the Arrayed Imaging Reflectometry (AIR™) Platform

Antigen Microarrays on the Arrayed Imaging Reflectometry (AIR™) Platform



Label-free microarray-based detection of autoantibodies in human serum
Bucukovski, J.; Carter, J. A.; Striemer, C. C.; Müllner, S.; Schulte-Pelkum, J.; Schulz-Knappe, P.; Miller, B. L. J. Immunol. Methods 2018 459, 44-49. PMID: 29802878

Crowd on a chip: Label-free human monoclonal antibody arrays for serotyping influenza
Zhang, H.; Henry, C.; Anderson, C. S.; Nogales, A.; DeDiego, M. L.; Bucukovski, J.; Martinez-Sobrido, L.; Wilson, P. C.; Topham, D. J.; Miller, B. L. Analytical Chemistry 2018 90, 9583-9590. PMID 29985597

A multiplex label-free approach to avian influenza surveillance and serology
Bucukovski, J.; Latorre-Margalef, N.; Stallknecht, D. E.; Miller, B. L. PLOS ONE 2015 10, e0134484 PMID 26241048

Examining the interactions of the splicing factor MBNL1 with target RNA sequences via a label-free, multiplex method
Yadav AR, Mace CR, Miller BL. Anal Chem. 2014 Jan 21;86(2):1067-75. doi: 10.1021/ac402603j. Epub 2014 Jan 9.

Comparative study of solution phase and vapor phase deposition of aminosilanes on silicon dioxide surfaces
Yadav, A. R.; Sriram, R.; Carter, J. A.; Miller, B. L. Mat. Sci. Eng. C 2014, 35, 283-290. PMID: 24411379

Analysis of inflammatory biomarkers by Arrayed Imaging Reflectometry
Carter JA, Mehta SD, Mungillo MV, Striemer CC, Miller BL. Biosens Bioelectron. 2011 May 15;26(9):3944-8. doi: 10.1016/j.bios.2011.02.025. Epub 2011 Feb 24.

Validation of arrayed imaging reflectometry biosensor response for protein-antibody interactions: cross-correlation of theory, experiment, and complementary techniques
Sriram R, Yadav AR, Mace CR, Miller BL. Anal Chem. 2011 May 15;83(10):3750-7. doi: 10.1021/ac2001302. Epub 2011 Apr 25.

Label-free, arrayed sensing of immune response to influenza antigens
Mace CR, Topham DJ, Mosmann TR, Quataert SA, Treanor JJ, Miller BL. Talanta. 2011 Jan 15;83(3):1000-5. doi: 10.1016/j.talanta.2010.11.002. Epub 2010 Nov 10.

Aqueous arrayed imaging reflectometry as a sensitive platform for real-time biomolecular interaction analysis
Yadav, A. R.; Mace, C. R.; Miller, B. L. Proc. SPIE, 2011, 7888, 78880I.

Multiplex detection of disease marker proteins with Arrayed Imaging Reflectometry
Yadav, A.; Sriram, R.; Miller, B. L. Proc. SPIE, 2010, 7553, 75530J-1.

Arrayed Imaging Reflectometry for inexpensive and label-free protein arrays
Striemer, C. C.; Mace, C. R.; Carter, J. A.; Mehta, S. D.; Miller, B. L. Proc. SPIE, 2009, 7167, 71670G.

Tracking serum antibody response to viral antigens with Arrayed Imaging Reflectometry
Mace, C. R.; Rose, R. C.; Miller, B. L. Proc. SPIE, 2009, 7167, 71670H.

Detection of human proteins using arrayed imaging reflectometry
Mace CR, Striemer CC, Miller BL. Biosens Bioelectron. 2008 Oct 15;24(2):334-7. doi: 10.1016/j.bios.2008.05.003. Epub 2008 May 27.

Theoretical and experimental analysis of arrayed imaging reflectometry as a sensitive proteomics technique
Mace CR, Striemer CC, Miller BL. Anal Chem. 2006 Aug 1;78(15):5578-83.