Arrayed Imaging Reflectometry (AIR™) is a silicon chip based label-free biosensor platform. It optically senses molecular binding at the chip surface by enabling the detection of any probe or target pair of analytes.

By functionalizing the surface with highly specific probe molecules (eg. antibodies, protein kinases, microRNAs, etc.) target binding can be detected and quantified directly with high sensitivity.  As a label-free technique, the assay procedure requires minimal process time. Comparable labeled techniques require two or three additional chemistry steps after target binding, typically resulting in process times greater than two hours and adding substantial reagent cost.

The low complexity of Adarza’s AIR method enables massive multiplexing, allowing hundreds and potentially thousands of unique probes to be arrayed on the chip surface for simultaneous detection without interference.

The flexibility of AIR enables for the first time the same technology platform to be used across the entire biomarker discovery and validation process through deployment in clinical and point of care diagnostics applications.

How It Works

AIR is based on the observation that the performance of a single layer antireflective (AR) coating is highly sensitive to the thickness of the film. This sensitivity increases as the reflectance approaches zero. Therefore, by precisely engineering a substrate with an AR coating that approaches zero reflectance, a sensor with the capacity to detect picoscale thickness changes on its surface is formed.

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Applications

Adarza’s ground breaking AIR technology offers tremendous flexibility across diverse applications.

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Literature

Our foundation technology was first described in 2006 and has been described and applied in over a dozen publications and patents.

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