Arrayed Imaging Reflectometry (AIR™) is a silicon chip based label-free biosensor platform. It optically senses molecular binding at the chip surface by enabling the detection of any probe or target pair of analytes.
By functionalizing the surface with highly specific probe molecules (eg. antibodies, protein kinases, microRNAs, etc.) target binding can be detected and quantified directly with high sensitivity. As a label-free technique, the assay procedure requires minimal process time. Comparable labeled techniques require two or three additional chemistry steps after target binding, typically resulting in process times greater than two hours and adding substantial reagent cost.
The low complexity of Adarza’s AIR method enables massive multiplexing, allowing hundreds and potentially thousands of unique probes to be arrayed on the chip surface for simultaneous detection without interference.
The flexibility of AIR enables for the first time the same technology platform to be used across the entire biomarker discovery and validation process through deployment in clinical and point of care diagnostics applications.